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Define optimise. optimise synonyms, optimise pronunciation, optimise translation, English dictionary definition of optimise. Past participle: optimised Gerund: optimising Imperative optimise optimise. To optimize a plan, system, or machine means to arrange or design it so that it operates as smoothly and efficiently as possible. Doctors are concentrating on optimizing the treatment. 5 meanings: 1. to. Dec 6, 2025 · Learn the difference between optimize or optimise, correct usage, examples, and region-based spelling for professional English writing. This dictionary definitions page includes all the possible meanings, example usage and translations of the word optimise. To optimise is to make something as effective, functional, or beneficial as possible. Optimize and optimise are both English terms. Optimize is predominantly used in 🇺🇸 American (US) English (en-US) while optimise is predominantly used in 🇬🇧 British English (used in UK/AU/NZ) (en.